منابع مشابه
Hematin: unique effects of hemostasis.
Hematin is clinically useful in the treatment of acute intermittent porphyria. Recently, hematin-induced coagulopathy has been reported, and a patient we treated bled during hematin therapy. On 3 separate occasions, infusions of hematin (4 mg/kg) induced thrombocytopenia, prolongation of the prothrombin time, partial thromboplastin time. Reptilase time, and apparent decreases in fibrinogen and ...
متن کاملHematin: Unique Effects on Hemostasis
Hematin is clincally useful in the treatment of acute intermittent porphyria. Recently, hematin-induced coagulopathy has been reported. and a patient we treated bled during hematin therapy. On 3 separate occasions. infusions of hematin (4 mg/kg) induced thrombocytopenia, prolongation of the prothrombin time, partial thromboplastin time. Reptilase time and apparent decreases in fibrinogen and in...
متن کاملAntimalarials inhibit hematin crystallization by unique drug-surface site interactions.
In malaria pathophysiology, divergent hypotheses on the inhibition of hematin crystallization posit that drugs act either by the sequestration of soluble hematin or their interaction with crystal surfaces. We use physiologically relevant, time-resolved in situ surface observations and show that quinoline antimalarials inhibit β-hematin crystal surfaces by three distinct modes of action: step pi...
متن کاملHeme arginate: effects on hemostasis.
Hematin, the drug used for acute porphyric attacks, has been shown to cause disturbances in hemostasis, mainly because of its degradation products. Lately a new heme compound, heme arginate, has been developed for the treatment of porphyrias. In experimental animal studies as well as in clinical use it has proved to be well tolerated. To find out whether heme arginate has any effects on hemosta...
متن کاملHematin formation and pancreatitis.
HEMORRHAGIC PANCREATITIS is a more lethal disease than edematous pancreatitis [2, 5, 81. For prognostic and therapeutic purposes it would be useful to be able to distinguish between the two forms of pancreatitis, but present methods are inadequate. Levels of serum amylase, an index of the degree of ductal obstruction of the pancreas, depend on a functioning acinar cell [l]. Amylase and lipase l...
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ژورنال
عنوان ژورنال: Blood
سال: 1983
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v61.2.243.bloodjournal612243